Syncly Social Index

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Skincare

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PDRN skincare on video, September 2026

What is PDRN?

PDRN (polydeoxyribonucleotide) is a mix of DNA fragments, usually purified from salmon or trout sperm cells, used in skincare for repair, plumping and glow. It began as an injectable in Korean clinics, where research links it to wound healing and reduced inflammation, and moved into serums, creams, masks and mists in 2025–26.

That origin is why creators call it "salmon DNA" or "salmon sperm" skincare. Newer launches use fermented or plant-derived PDRN instead.

Source: Squadrito et al., "Pharmacological Activity and Clinical Use of PDRN", Frontiers in Pharmacology.

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Share of beauty videos by month

Monthly share of beauty videos that mention the term.

10%
7.3%
7%
8%
Jun 26Jul 26Aug 26Sep 26

Which brands own the conversation

Share of the term’s videos that mention each brand.

Medicube27%
Anua10%
VT Cosmetics (Reedle)7.8%
Mixsoon4.9%
Centellian243.8%
Rejuran3.6%
Mediheal1.5%
Skintific0.8%

Most-mentioned products

Products named most often alongside the term.

ProductVideos
Medicube PDRN Pink Peptide Serum
1,989
Medicube PDRN Pink Collagen masks
1,160
Anua PDRN Hyaluronic Acid Capsule 100 Serum
971
Anua PDRN Hyaluronic Acid 100 Cream
838
Medicube PDRN stick / multi balm
753
Anua PDRN Capsule Mist
742
VT Cosmetics Reedle Shot (PDRN mentions)
738
Dr. Reju-All Advanced PDRN Cream
528
L'Oréal Paris Revitalift HA+PDRN (brand)
382
Biodance (Caviar PDRN line)
321
Abib PDRN (retinal eye patch etc.)
318

Said in the video, not the caption

How often the term is only spoken or shown on screen, with no caption or hashtag mention.

Said only in the videoAlso in the caption or hashtags
All videos
45%
55%
Everyday creators
60%
40%
Top 30 videos
30%
70%
Top 30 videos, weighted by views
19%
81%

How creators explain it

What videos say when they describe the trend.

Pairing with other actives35%median 1.1M views
Benefit claims31%median 1.1M views
No explanation given28%median 1.1M views
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Share of sampled videos that explain the trend this way (a video can use several).

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Hooks that open the videos

The opening line or visual each video uses, with an example for each hook type.

Product reveal / unboxing / haul21%median 1.3K views · 50% sponsored
“L'Oréal Paris serum PDRN mới cho da trông căng mọng rạng rỡ tức thì, cảm nhận làn da glass skin” — @lorealparis_vn, 15M views · Watch ↗
Routine / GRWM17%median 1.1M views · 31% sponsored
“Hello, I wanted to show you guys my Anua skincare routine today. I like to start with my Anua PDRN” — @kendalljenner, 9.8M views · Watch ↗
POV / storytime11%median 2M views · 50% sponsored
“pov you have brown eyes...” — @janellezharmenova, 13M views · Watch ↗
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Share of sampled videos opening with each hook type.

What this means for marketers

Reach comes from incidental mentions

Name-drops inside makeup, POV and routine videos had the highest median views (2.03M) of any angle. Lifestyle creators buy reach. They don't explain the ingredient.

Salmon origin is the explainer that travels

9 of the 10 videos that named PDRN's salmon origin were in the top 45, with a 2.0M median, about 1.5× other explainers.

The clinic angle is open

Only 5% of videos tie PDRN to skin-booster injections, and none explain how a serum differs from a clinic treatment. Honest clinic-vs-serum framing is uncontested.

Myth-busting reaches without paid support

Myth-busting hooks averaged 1.53M median views with just 12% sponsored, the lowest paid share of any hook.

Unboxing seeding rarely breaks out

Product reveals are 43% of everyday PDRN videos, with an 830-view median. Seeding briefs need a hook beyond "unbox with me".

Fermented PDRN needs a contrast

Vegan and fermented claims trail salmon-origin explainers (1.17M vs 2.0M median). L'Oréal framed its fermented PDRN against salmon and drew 15.1M views (watch).

Top videos

The most-viewed videos mentioning the term this month.

@lorealparis_vn · TikTokBrand ad: Revitalift HA+PDRN serum, 'fermented PDRN 3x stronger than salmon PDRN', instant glass skinOpen on TikTok ↗
@janellezharmenova · InstagramFall burgundy eye makeup tutorial; PDRN only via product tag list in caption (#ad)Open on Instagram ↗
@kendalljenner · InstagramKendall Jenner #AnuaPartner routine: PDRN serum, mist, cream for hydrated glowy skinOpen on Instagram ↗
@skincare.zombie · InstagramComedic 'getting dumped' pre-date routine; Axis-Y PDRN gel toner listed in captionOpen on Instagram ↗
@dr.ljmaxfield · TikTokPaid derm explainer of Booster Pro X2; recommends pairing device with a PDRN serum for firmer lookOpen on TikTok ↗
@emrecansinikoglu · Instagram#reklam: Anua launches at Watsons Turkey, product picks incl. PDRN lineOpen on Instagram ↗
@masbearzt · TikTok#publi Primor 3x2 promo; Revitalift Filler HA+PDRN 'anti-wrinkle, fills, hydrates'Open on TikTok ↗
@prettytitiii01 · TikTokCouple night routine; Medicube PDRN pink vita coating mask for 'glassy' skinOpen on TikTok ↗

What skeptics say

Creators pushing back on the trend, with links to each video.

@nipunkapur442K viewsAnua PDRN Serum in BIN list: low active PDRN dosage, functions like a basic HA serumOpen on Instagram ↗
@drsomji266K viewsDerm 'buy or not' trends: PDRN cream - limited absorption/evidence, wouldn't buyOpen on TikTok ↗
@yesjules_143K viewsMedicube PDRN Pink Peptide Serum = PASS: topical PDRN evidence too limited for anti-agingOpen on TikTok ↗
@james_s_welsh127K views'We all know the topical limits of PDRN'; Medicube pushes claims furtherOpen on TikTok ↗
@yes_jules109K viewsIG cross-post of the same invest/pass video (Medicube PDRN serum = pass)Open on Instagram ↗

Frequently asked questions

PDRN (polydeoxyribonucleotide) is a mix of DNA fragments, usually from salmon or trout, used in serums, creams and masks for repair, plumping and glow. It started as a clinic injectable in Korea and moved into topical skincare in 2025–26.
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